Piperine is an alkaloid that, like piperine, is the source of the spicy flavor of black pepper. It is used in some forms of traditional medicine and pesticides. We offer piperine extract powder bulk at DAYU.
The spicy taste caused by capsaicin and piperine is caused by opening the TRPV ion channel in the pain nerve, the TRPV-1 channel that is used to sense heat and sour taste.
In addition, piperine has been found to inhibit cytochrome and P-glycoprotein, two enzymes that play an important role in metabolism and the transport of heteroplasms and metabolites. In animal experiments, scientists have found that piperine can also inhibit other enzymes that play an important role in drug metabolism. In other words, the bioavailability of piperine itself is not very high, but the effect of helping others to improve bioavailability is immediate. Piperine does improve the bioavailability of a variety of drugs and nutrients (such as harringtonine, platypus alkaloid, quercetin, resveratrol, coenzyme Q10, vitamin B6, etc.). For example, piperine can effectively increase the bioavailability of curcumin in the human body by 2000%. Because of the above-mentioned inhibitory effect on drug metabolism, patients who are taking drugs should take piperine carefully to avoid side effects.
The selected dried black and white pepper fruit are crushed into pepper powder of a certain size; the crushed pepper powder is mixed with two or more mixed organic solvents and mechanically stirred to separate the solid powder from the liquid mixture; all the extracted solution is added to the distillation kettle to separate the organic solvent. After steaming out the organic solvent, the concentrate is pepper oleoresin with a high proportion of piperine.
The pepper oleoresin containing a high proportion of piperine can be successfully crystallized from the mixture by cooling method, and the crude crystallization contains a small amount of pepper oleoresin. Then the crude crystallization is recrystallized many times with solvents such as dichloroethylene or ethyl acetate, thus the piperine with high purity can be obtained.
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